The Challenge Cup draw has just been made, with the live draw being held on the BBC Sport website as well as Look North from 6:45pm.
The sixth round will feature Super League teams for the first time, as well as a number of expectant Championship sides looking to cause an upset.
The holders are, of course, St Helens, and they will be looking to recapture their scintillating cup form with the ties set to be played on the weekend of March 25-27.
The Sixth Round draw in full:
Catalans Dragons vs Featherstone Rovers
Whitehaven vs St Helens
Warrington Wolves vs Wakefield Trinity
Hull KR vs Bradford Bulls/Leigh Centurions
Wigan Warriors vs Salford Red Devils
Leeds Rhinos vs Castleford Tigers
Sheffield Eagles vs Hull FC
Barrow Raiders vs Huddersfield Giants